NFE2L2 and Granuloma: The present study first demonstrated that in the BLM-induced lung injury and fibrosis model inhalation of DE increased the HOP content in the lung tissues in Nrf2+/+ mice to a greater extent than in Nrf2−/− mice; inhalation of DE also induced granulomas in the lung tissues to eliminate the intracellular DEP observed only in Nrf2+/+ mice.