CTHRC1 and neoplasm: The results indicated that the expression level of CTHRC1 was closely associated with clinical stages (P = 0.0021), pathology grade (P = 0.0186) (Fig. 3C and D), lymph metastasis (P = 0.0075) (Fig. 3E and F), Lymphatic vascular invasion (P = 0.001), deep of invasion (P = 0.0001) and diameter of tumor (P < 0.0001) (Table 1).