CTHRC1 is highly expressed in cervical cancer and promotes cervical cancer cell migration and invasion in vitro and metastasis in vivo. CTHRC1, an extracellular matrix protein, is secreted by cervical cancer cells and acts in a paracrine manner for regulating stromal cells in cancer microenvironment, eg. immune cells, fibroblast and endothelial cells, to influence the invasion and metastasis of cervical cancer. This evidence concerns the gene CTHRC1 and cancer.