Among the significant downregulated genes, the gene with the highest effect size was PLSCR4, encoding for the Phospholipid Scramblase 4, which has been found to be strongly expressed in the neuropil of malignant gliomas and in cytoplasm of liver cancers, colorectal cancers and malignant melanomas (http://www.proteinatlas.org/ENSG00000114698-PLSCR4/cancer). The gene discussed is PLSCR4; the disease is malignant glioma.