In summary, APS induces the expressions of mRNAs and proteins of TLR4, TRAF-6, NF-κB and AP-1, as well as increasing the levels of TNF-α and IL-6 in the serum of the TLR4+/+ tumor-bearing mice, but not TLR4−/− tumor-bearing mice. This evidence concerns the gene TLR4 and neoplasm.