Four of the 48 smoking-associated CpGs and cg08362785 in MKL1 were also associated with prevalent diabetes; of these 5 sites, cg18181703 in SOCS3 was also recently identified to be associated with type 2 diabetes (T2D)5,25 and cg23190089 is located at SLC22A18AS, a locus near to known methylation-regulated genes implicated in T2D26,27. This evidence concerns the gene MRTFA and type 2 diabetes mellitus.