This also applies to most of the other genes known to be related to specific diseases whose relationship to methylation-relevant outcomes were first disclosed in our study, such as DNAm of SARS, VCAM1, KCNQ1OT1, MIR19A, SEMA7A, BCL3, PPP1R15A and PDE9A for CVD, DNAm of SQLE, MIR19A, MIR10A, SOCS3, CALR, BCL3 and SLC1A5 for lung cancer, and DNAm of ATL3, SHANK2 and PPP1R15A for neurological diseases. The gene discussed is SHANK2; the disease is nervous system disorder.