In the larger FLEX study (N = 1125), evaluating cetuximab and cisplatin/vinorelbine vs cisplatin/vinorelbine alone as first-line treatment in selected EGFR-expressing advanced NSCLC patients [14], the slight improvement in ORR (36% vs 29%) was associated with a statistically significant improvement in OS, but the effect was very modest (11.3 vs 10.1 months; HR 0.871; p = 0.044). This evidence concerns the gene EGFR and non-small cell lung carcinoma.