Because of this, first-line single target pharmacological therapies for AD, acetylcholinesterase (AChE) inhibitors (e.g., donepezil) and N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., memantine), are not particularly effective, boosting cognitive function in the early disease stages only, and are unable to slow or stop the disease progression [7, 8]. Here, ACHE is linked to Alzheimer disease.