RAGE has been shown to play an essential role in the production of NETs and the treatment of neutrophils with anti-RAGE antibodies prevents NET formation induced either by activated platelets or by recombinant HMGB1, suggesting that Aβ or HMGB1 inside vessels may interact with neutrophil RAGE leading to NET formation in AD (83). This evidence concerns the gene HMGB1 and Alzheimer disease.