TLR4 and Alzheimer disease: Intravascular NETs may be induced by activated platelets interacting with neutrophils via Toll-like receptor 4 (TLR4) or LFA-1 integrin, and we speculate that the release of intravascular NETs found in AD mouse models and human AD subjects could be promoted by activated platelets interacting with adherent neutrophils (56, 59, 85).