In the present study, TD participants show decreases in both S. Typhi-responsive integrin α4β7− and integrin α4β7+ CD8+ TEM cells after challenge, suggesting that migration of the CD8+ TEM might be associated with the development of typhoid fever and that S. Typhi-responsive TEM cells migrate not only to mucosal sites but also to other sites, presumably other RES components (e.g., peripheral lymph nodes, spleen). Here, CD8A is linked to typhoid fever.