The downregulation of ZIP14 expression and the upregulation of ZNT1 expression in obese subjects are indicative of a reduction in free cytoplasmic zinc, with potential down-stream effects on PPARG, RBP4, and GLUT4 expression, as well as RBP4 appear to be directly involved in PCOS pathology. The gene discussed is SLC30A1; the disease is polycystic ovary syndrome.