PPARG and obesity due to melanocortin 4 receptor deficiency: Two-way ANOVA analysis showed a significant downregulation of PPARG1 expression by obesity (p < 0.0001; subgroup analysis examining lean PCOS vs. obese PCOS, and lean controls vs. obese controls using Student’s t-test; p = 0.0001 and p < 0.0001, respectively).