As shown by the two-way ANOVA analysis, the adipose expression of GLUT4 was significantly downregulated by the presence of obesity (p = 0.0009), evident in subgroup analysis using Student’s t-test when comparing obese controls vs. lean controls (p = 0.0185, t-test) and tending toward statistically significance when comparing lean PCOS vs. obese PCOS (p = 0.0547, t-test). The gene discussed is SLC2A4; the disease is obesity due to melanocortin 4 receptor deficiency.