Knowing that both circulating and tissue cytokines are important in triggering acute kidney injury induced by cisplatin (Arany and Safirstein, 2003; Yao et al., 2007; Miller et al., 2010), we analyzed serum levels and tissue expression of the main cytokines and observed lower serum levels of TNF-α and IL-1β in the CR group than in exercise group. This evidence concerns the gene IL1B and acute kidney injury.