Autoantibodies to ZnT8 (ZnT8A) complement the established set of type 1 diabetes-associated autoantibodies to insulin (IAA), glutamic acid decarboxylase (GAD65A), and protein tyrosine phosphatase (insulinoma-2 antigen antibody, IA-2A), which are important for predicting and confirming the T1D diagnosis5. This evidence concerns the gene INS and type 1 diabetes mellitus.