We believe that K119E/R120E and K125E of FGF2 may not induce such mutations in FGFR because the FGF2 mutants bind to FGFR exactly the same way as WT FGF2 and block binding of FGF2 (and other members of the FGF family) to FGFR would not benefit cancer cells. Here, FGF2 is linked to cancer.