CCN1 and neoplasm: In microbead-treated mice versus vehicle controls, there were increases in the circulating levels of delta-like ligand protein (DLL) 4, fibroblast growth factor (FGF) 7, fractalkine, IGFBP10, IL10, and TP (Fig. 5A-F), all of which are involved in either angiogenesis or inflammation, processes that are essential for successful tumour establishment.