In a similar vein, the galectin from the feline intestinal nematode Toxascaris leonina, provided modest protection against disease activity in DSS-induced colitis, while raising IL-10 and TGF-β responses (87), while a schistosome enzymatic protein, the 28-kDa glutathione-S-transferase, P28GST) conferred a protective effect that was dependent on eosinophil infiltration, as the effect was absent in IL5−/− mice (38). This evidence concerns the gene TGFB1 and colitis.