While in human ulcerative colitis, IL-22+ T cells were linked to amelioration of symptoms (17), in Crohn’s disease, the expression of IL-22+ T cells within inflamed mucosa act to increase expression of inflammatory cytokines within subepithelial myofibroblasts, and so the role of IL-22 may be highly context dependent. The gene discussed is IL22; the disease is ulcerative colitis.