Interestingly, the macrophage migration inhibitory factor (MIF) homolog from Anisakis simplex (As-MIF) has also been shown to induce upregulation of IL-10 in both lymph node and intestinal epithelial cells, and also increases Foxp3+ Treg expression in mice subject to DSS-induced colitis (23). Here, FOXP3 is linked to colitis.