Significantly, the roles of hsa-mir-148b, hsa-mir-181b, hsa-mir-18a, hsa-mir-19a, and hsa-mir-221 in HCC through interactions with ESR1 and CXCL12 may provide new clues for the diagnosis and treatment of HCC patients. The gene discussed is CXCL12; the disease is hepatocellular carcinoma.