Increased expression of these microRNAs might be involved in the autoimmune neuroinflammation and pathogenesis of multiple sclerosis through changing the pattern of T cells differentiation towards IFN-γ-producing Th1 cells; an effect which might be mediated through targeting and suppression of protective genes such as TGFBR1 and SOCS1. This evidence concerns the gene TGFBR1 and multiple sclerosis.