If this is the case, then it is feasible that the activation of such a pathway which allows for an increased ability to respond to the pro-metastasis signalling of a combination of TGF-β1 and Hsp90β could be responsible for the spread of cancer from the primary tumour to the lymph node in the patient from whom the genetically paired cell lines were derived. Here, TGFB1 is linked to neoplasm.