By a comparison to the random positions having matched base-pair composition along the lost dREs, we noticed that the detected CLL-associated substitutions are associated with the loss of binding site of P53, NFKB2, E2F1, and PAX5 more frequently than expected (enrichment of TFBS loss > 1.5 and p < 0.05, Fig. 6b and Additional file 2: Table S8). Here, E2F1 is linked to B-cell chronic lymphocytic leukemia.