Kaempferol-glucopyranoside could inhibit the proliferation of rat hepatic stellate cells, the major cell type involved in liver fibrosis in response to liver damage, via down-regulating the mRNA expressions of collagen I, collagen III, Smad2, Smad3, and up-regulating the mRNA expression of Smad7 (Zhou et al. Here, SMAD3 is linked to Hepatic fibrosis.