2010). In CCl4 induced liver fibrosis rat model, treatment with TFLC 200 mg/kg reduced the serum levels of ALT, AST, hyaluronic acid, laminin, procollagen III N-terminal peptide, procollagenase IV, collagen I, leptin, and TGF-β1. Additionally, TFLC suppressed the mRNA and protein expressions of leptin receptor (Ob-Rb), TGF-βR1, and Smad3 in liver (Huang et al. 2012). The gene discussed is SMAD3; the disease is Hepatic fibrosis.