A review by Kostner et al (Kostner et al, 2009) concluded that associations between VDR polymorphisms and cancer prognosis are strongest for prostate cancer (rs2228570), breast cancer (rs1544410, rs731236) malignant melanoma (rs1544410), and renal cell carcinoma (rs731236) but did not perform meta-analysis on these data. This evidence concerns the gene VDR and hereditary clear cell renal cell carcinoma.