VDR and cancer: Indeed, Han et al (Han et al, 2007) have shown an interaction between vitamin D intake and rs1544410 polymorphism on cancer risk, and we and others have previously shown a modification of the relationship between vitamin D intake or status and cancer outcome by other VDR variants, thus suggesting an interaction of genetic and environmental factors (Li et al, 2007; Theodoratou et al, 2008; Anderson et al, 2011; Zgaga et al, 2014).