For primary CML cells without the BIM deletion polymorphism, we observed that at least 10 nM of SB939 was able to induce a 55% net apoptotic cell death, similar to that induced by 2 uM of IM, and that co-treatment with 2 uM IM did not significantly increase apoptotic cell death (Fig 4A). This evidence concerns the gene BCL2L11 and chronic myelogenous leukemia, BCR-ABL1 positive.