SB939, however, can reverse the effect by reducing the ratio of exon 3- to exon 4-containing BIM transcripts (Fig 1A) which, translated to a significant increase in the induction of apoptosis in CML cells with the BIM deletion polymorphism (Fig 1B and 1C). Here, BCL2L11 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.