Fig 1 shows that knockdown of S6K2 caused a modest (Fig 1A) but significant (Fig 1B) decrease in the clonogenic survival of T47D breast cancer cells. Moreover, knockdown of S6K2 but not S6K1 enhanced apoptosis induced by TRAIL (Fig 1C) and doxorubicin (Fig 1D) as evidenced by the increase in the cleavage of PARP and the generation of cleaved caspase-3. This evidence concerns the gene CASP3 and breast cancer.