The observation that QPD dysregulates PLAU but not C10orf55 (the other duplicated gene) in megakaryocytes, and that QPD increases production of normal PLAU transcripts from the disease chromosome in megakaryocytes [1], provides further evidence that a megakaryocyte specific defect that selectively upregulates PLAU transcript levels underlies the pathogenesis of QPD. Here, PLAU is linked to Quebec platelet disorder.