SAMP mice showed the presence of tubular adenomas and tubular adenomas with high-grade dysplasia, which were absent in the colons of AKR mice (inflammatory score: AKR = 1.000 ± 0.7123 vs. SAMP = 1.628 ± 0.1326; P = 0.0016) (Fig 5E). The gene discussed is XPNPEP1; the disease is tubular adenoma.