ESR1 and neoplasm: Older than 70 years (OR, 0.89; 95% CI, 0.09–8.27; I2 = 97.2%), worse comorbidity status (OR, 1.17; 95% CI, 0.86–1.58; I2 = 63.6%), poorer histological differentiation (OR, 0.58; 95% CI, 0.30–1.10; I2 = 96.9%), presence of lymphatic vascular invasion (OR, 0.90; 95% CI, 0.80–1.02; I2 = 0.0%), higher TNM stage (OR, 1.09; 95% CI, 0.64–1.84; I2 = 72.1%), involved nodes ≥10 (OR, 0.90; 95% CI, 0.73–1.11; I2 = 0.0%), tumor size > 5cm (OR, 1.24; 95% CI, 0.63–2.42; I2 = 58.0%) and ER / PR positive status (OR, 1.33; 95% CI, 0.94–1.87; I2 = 86.0%, Fig 3) were not correlated with an increased risk of DAC.