GSEA revealed a dramatic difference between the enrichment of AML-activated genes in dLOCKCD34+>AML and enrichment of AML-repressed genes in dLOCKAML>CD34+ (Fig 6B and 6C and Table D in S7 Table), suggesting that transcriptional repression of multiple genes in AML is associated with the AML-enriched H3K9me2 blocks. The gene discussed is CD34; the disease is acute myeloid leukemia.