We chose genes belonging to the two regulatory pathways: TRIM28-regulated KRAB-ZFP (ZNF) genes most represented in dLOCKs depleted in AML but not reduced by G9a inhibition and ERG-regulated genes (ERG, ETS1, MECOM) residing in the dLOCKs gained in AML and strongly reduced by G9a inhibition in K562 cells (Fig 7D). Here, ERG is linked to acute myeloid leukemia.