CTCF and acute myeloid leukemia: For the top-scoring genes associated with dLOCKCD34+>AML and upregulation in AML, Ingenuity® pathway analysis of upstream transcriptional activators revealed several transcriptional regulators including CTCF and RAF21 (Fig 6D) but not TRIM28 apparently because, although its target KRAB-ZFP genes are enriched in H3K9me2, they are known to resist silencing by G9a/GLP [17].