Future experiments on H3K9me2 mapping and G9a/GLP inhibition including functional tests for stem cell characteristics in primary and cultured AML-derived cells (such as KG-1 or HL-60) as well as analysis of homogeneous populations of pre-leukemic stem cells are needed to reveal the role of heterochromatin in repressing the proto-oncogenes and associated stem cell features in AML leukemia and pre-leukemia states. Here, EHMT2 is linked to leukemia.