We chose genes belonging to the two regulatory pathways: TRIM28-regulated KRAB-ZFP (ZNF) genes most represented in dLOCKs depleted in AML but not reduced by G9a inhibition and ERG-regulated genes (ERG, ETS1, MECOM) residing in the dLOCKs gained in AML and strongly reduced by G9a inhibition in K562 cells (Fig 7D). The gene discussed is TRIM28; the disease is acute myeloid leukemia.