To answer these questions, we developed a new approach to genome-wide analysis of large H3K9me2 blocks (Fig A in S1 File) and applied it to human myeloid cells including mature granulocytes, CD34+ progenitor cells, cultured K562 myeloid cells, and 10 samples of primary cells from the peripheral blood of AML patients. This evidence concerns the gene CD34 and acute myeloid leukemia.