Therefore, we calculated differential LOCKs (dLOCKs) of H3K9me2 for six comparison categories: two representing epigenetic changes during normal myeloid differentiation (CD34+ > granulocytes and granulocytes > CD34+) and four representing epigenetic changes between AML and normal cells (CD34+ > AML type A; AML type A > CD34+; granulocytes > AML type A; AML type A > granulocytes). The gene discussed is CD34; the disease is acute myeloid leukemia.