The most prominent among the H3K9me2 blocks depleted in AML A (dLOCKCD34+>AMLA) are gene-rich clusters containing multiple repeats of ZNF genes (KRAB-ZFP, zinc finger proteins containing a Kruppel-associated or KRAB domain [63]) genes on chromosome 19 and elsewhere in the genome (Fig 4 and the top lanes in Tables C and E in S5 Table). Other examples of large repeated gene families within the dLOCKs depleted with H3K9me2 in AML include repeats of small nucleolar RNA SNORD116 and SNORD115 on chromosome 15 and clusters of protocadherin genes on chromosome 5 (lanes 12 and 32 in supp. Here, PCDH11X is linked to acute myeloid leukemia.