Recent research has reported that an estrogen receptor agonist also induces IL-10 production in Th17 cells.42 As an estrogen-dependent inflammatory disease (Figure 8), in the initiation stage of endometriosis, cytokines, high estrogen and TCDD exposure significantly promote macrophages in the local microenvironment of ectopic foci to secrete a high level of IL-27. This evidence concerns the gene ESR1 and endometriosis.