In many cases, the expression of CD95L is even increased with tumor progression, suggesting that non-apoptotic signaling is dominant in the context of (colon) cancer development.3 CD95 stimulation can promote tumorigenesis by stimulating tumor cell invasion,8, 9, 13, 14, 15 proliferation,16 epithelial–mesenchymal–transition (EMT),17 and cancer stem cell maintenance.18 Recent data further suggest that there is a general requirement for CD95 and CD95L expression for tumor cell survival across tumor types,19 although the key signaling pathways underlying this dependency are currently not known. Here, FAS is linked to cancer.