It is well known that DNMT3A is essential for de novo methylation and inactivated DNMT3A may have close relationships with cancers.23, 24, 49 Owing to lncRNA biological role as a scaffold to recruit proteins, which can modulate the gene nearby, afterward, we perform RNA pull-down assay, protein mass spectrometry RIP assay to interact between Linc00441 and DNMT3A. This evidence concerns the gene DNMT3A and cancer.