In both wild-type and 3xTg-AD slices, there was a marked correlation between the amount of dephosphorylated tau present at membranes and the extent of tau release, in keeping with reports that tau localisation is important for its propagation.27 Taken together, these results suggest that the mechanisms governing the release of physiological and pathological forms of tau may be differentially regulated by neuronal stimulation. This evidence concerns the gene MAPT and Alzheimer disease.