Previous studies suggested that the prevalence of CD24-/CD44+ CSCs in breast tumors was linked to distant metastasis.51 In contrast, not all breast cancer cell lines containing high percentages of CD24-/CD44+ CSCs could give rise to lung metastasis.27 In addition, analyses of breast cancer samples showed that total CD44 expression can't predict distant metastasis efficaciously (Figure 5f and Supplementary Figure 7A). The gene discussed is CD44; the disease is breast carcinoma.