Both compounds were more potent against proliferation of these lymphocytic cell lines compared with myeloid leukemias, for which concentrations above 100 μM were required.40 This surprising effect suggests that lymphocytic leukemias are more sensitive to isoprenoid depletion relative to myeloid leukemias and that inhibition of GGDPS is more anti-proliferative than inhibition of FDPS. The gene discussed is FDPS; the disease is lymphoid leukemia.