The sidechain of R425 makes polar contacts with E352 in H4/5 of the PPARγ LBD, but does not appear to contact RXRα LBD directly.38 Thus, a pathogenic variant in the PPARγ LBD associated with partial lipodystrophy can potentially impact on the formation of PPARγ/PNR heterodimers. Here, NR2E3 is linked to partial lipodystrophy.