Interestingly, retinal changes are sometimes observed in patients with acquired partial lipodystrophy.67, 68 Crystal structures suggest that R425C does not participate in direct contacts with the RXRα LBD,48 although it is located close to the heterodimer interface, and therefore may have a role in contacting the PNR LBD. Here, NR2E3 is linked to partial lipodystrophy.