With the exception of the P12A polymorphism, genetic variants in the PPARγ gene are rare and LBD variants have been associated with familial partial lipodystrophy type 3, leading to loss of fat tissues at the extremities combined with insulin resistance and type 2 diabetes.46 These mutations generally result in loss of function and reduced transcriptional activity of PPARγ. This evidence concerns the gene PPARG and type 2 diabetes mellitus.