For instance, WDR5 has central roles in the proliferation of androgen-dependent prostate cancer cell, and its protein expression levels are positively correlated with poor survival in breast and bladder cancer.15, 17, 18 Nevertheless, none of these studies has elucidated the functional mechanism of action of WDR5 in CRC metastasis. This evidence concerns the gene WDR5 and Familial prostate cancer.