A cohort study of leukemia patients suggested that WDR5 may have oncogenic effects in leukemogenesis.15 In addition, researches show that WDR5 has high expression level in prostate cancer, bladder cancer, and breast cancer, and has a positive correlationship with advanced stage and poor survival.16, 17, 18 It is well established that CRC may share some similarities with these other types of cancer. Here, WDR5 is linked to urinary bladder cancer.