WDR5 and cancer: In addition, WDR5 mediates somatic cell reprogramming and embryonic cell self-renewal, while epithelial–mesenchymal transition (EMT) was reported to participate in the achievement of stemness as a key step.19, 20 Therefore, these achievements suggest that WDR5 might have an oncogenic role to play in the early steps of the invasion–metastasis cascade by regulating EMT to enable cancer cells to invade deep into the stroma, and then translocate to distant parenchyma.