Further, to examine endogenous WDR5 protein expression, we performed immunohistochemistry (IHC) on histopathologically confirmed CRC tissue sections with paraffin-embedded (n=161; for more information, see Supplementary Table S1).Results showed a markedly higher level of WDR5 protein expression in tumor tissues than that compared to paired non-tumor mucosal tissues (Figure 1d and e,Supplementary Figure S1A; P<0.001). The gene discussed is WDR5; the disease is neoplasm.