HIF1A and colorectal carcinoma: Third, WDR5 was reported to interact with HDAC3, resulting in a recruitment of a histone methyltransferase complex and the activation of mesenchymal gene expression under hypoxic conditions.39, 40, 41 Indeed, qRT-PCR analysis of CoCl2-treated CRC cells showed a dose-dependent activation of HIF1-α, followed by the upregulation of WDR5 expression (data not shown).