PIK3CA and Familial prostate cancer: Recent studies have presented that PI3K/AKT pathway activation is a key character of EMT.21 One study in prostate cancer demonstrated a relationship between radioresistance and EMT via overactivating the PI3K/AKT/mTOR signaling pathway.22 Another study showed that activated AKT causes EMT based on the regulation of EMT-specific markers in human squamous cell carcinoma lines.23 Moreover, Riquelme E et al.24 advocated a methyltranferase, EZH2, was modulated by the PI3K/AKT transduction pathway in lung cancer.