XIAP and acute pancreatitis: The effect of LPS on pancreatic tissue and inflammatory response have been evaluated, which showed intraperitoneal injection of LPS increases serum cytokine level but did not likely induce obvious pancreatic pathology, including cell death.36, 37 Importantly, all parameters quantifying the severity of acute pancreatitis were reduced in XIAP-deficiency mice as compared with wild-type mice, especially in the cerulein+LPS-induced model.