NFKB1 and pancreatitis: NF-κB-dependent anti-apoptotic gene transcriptional activation has been demonstrated to be crucial in regulating cell death in pancreatitis.2, 3, 47 Thus, deletion of XIAP decreases the activation of NF-κB, resulting in less release of inflammatory cytokines, decreased necrosis and increased apoptosis, all of which contribute to attenuate the severity of acute pancreatitis.