RIP1 forms a death-signaling complex with the Fas-associated death domain and caspases in response to death domain receptor stimulation.23, 24, 25, 26 During apoptosis, RIP1 is cleaved/inactivated by caspase-3 and -8,27 it can also be regulated by XIAP.28, 29 The regulation of RIP1 has been suggested to be one of protective mechanisms against necrosis in cerulein-induced pancreatitis.3, 30. The gene discussed is CASP3; the disease is pancreatitis.