NF-κB-dependent anti-apoptotic gene transcriptional activation has been demonstrated to be crucial in regulating cell death in pancreatitis.2, 3, 47 Thus, deletion of XIAP decreases the activation of NF-κB, resulting in less release of inflammatory cytokines, decreased necrosis and increased apoptosis, all of which contribute to attenuate the severity of acute pancreatitis. This evidence concerns the gene XIAP and pancreatitis.