CST1 and colorectal carcinoma: We previously reported that CST1 is significantly overexpressed in colorectal and gastric cancer, resulting in enhanced tumor cell growth and invasiveness.9, 11 In this study, we evaluated the role of CST1 upregulation on AF activation of autophagy-induced cell death in CRC cell lines and found that CST1 modulates AF-induced ROS production via thioredoxin reductase.