There are many key regulators or signaling pathways that play important roles in colorectal cancer chemo- and radio-therapies, such as p53, NFκB, non-coding RNAs and etc.37, 38, 39 At this time, there is a lack of gene expression data derived from CC patients that could suggest that NCAPH high level expression is important for predicting sensitivity to chemo- and/or radio-therapies. This evidence concerns the gene TP53 and colorectal cancer.