NCAPH and colonic neoplasm: It has been demonstrated that condensing I complex is excluded from nucleus until nuclear envelope breakdown, which is in line with the findings that no inhibition of prophase chromosome condensation occurs after condensing I knockdown.21, 22 Consistent with the spatial regulation of NCAPH, both cytoplasm and nuclear expressions of NCAPH were detected in colon tumors and adjacent normal tissues, and NCAPH expression was higher in colon cancerous tissues than that in the normal tissues (Figures 1a–b′).