As is well known, high-risk HPVs (HPV16, 18, etc.)are important risk factors in various tumors; most cases of cervical cancer are associated with HPV infections, such as HPV16 and HPV 18 infections.29, 41, 42 Therefore, the results of our study also identify MCM7 as a potential therapeutic target not only in RB-deficient tumors but also in HPV-expressing malignancies, thereby broadening the significance of our findings. This evidence concerns the gene RB1 and cervical carcinoma.