As shown in Figures 1c and d, MCM7 depletion resulted in stronger expression of γ-H2AX after HPV E7 adenovirus infection in SiHa and U2OS cells, and MCM7 depletion induced a weaker expression of γ-H2AX in PSM-RB adenovirus-infected C33A and SaOS2 cells. The gene discussed is RB1; the disease is adenoviridae infectious disease.