TIM-3 is expressed on TAMs in a variety of tumors, including hepatocellular carcinoma, lung cancer, clear cell renal cell carcinoma, osteosarcoma, Langerhans cell sarcoma, and neoplasms derived from histiocytic and dendritic cells [89,90,91,92,93]. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.