TIM-3 was also shown to be expressed in TIL or tumor antigen-specific T cells in peripheral blood from many cancer types such as hepatocellular cancer, cervical cancer, colorectal cancer, ovarian cancer [55], NSCLC [56,57], head and neck cancer [58], renal cell carcinoma (RCC) [59], gastric cancer [60], esophageal cancer [61], prostate cancer [62], and non-Hodgkin lymphoma [63]. The gene discussed is HAVCR2; the disease is renal cell carcinoma.