Immunodetection of VRS especially VDR and FGF23 in osteoblastic core of OS-TMAs is interesting as previous studies have reported tumor promoting effects of FGF23 either directly or indirectly by affecting the bioavailability and catabolism of 1α,25(OH)2D3 which in turn is important for mediating antineoplastic functions [26,58]. The gene discussed is VDR; the disease is neoplasm.