Global knockout of Kir4.1 leads to postnatal lethality (Neusch, Rozengurt, Jacobs, Lester, & Kofuji, 2001), whereas conditional Kir4.1 knockout in astrocytes alone is able to trigger epilepsy (Chever, Djukic, McCarthy, & Amzica, 2010; Haj‐Yasein et al., 2011a). Here, KCNJ10 is linked to epilepsy.