HDAC1 and schizophrenia: In contrast, inducing the si-RNA-mediated knockdown of HDAC1 or the pharmacological inhibition of HDAC1 impaired learning and increased cell death (Kim et al., 2008), and these results correspond rather well with our observations in the OBs, in which schizophrenia-like phenotype led to the depletion of HDAC1 (Figure 7a,b,b2).