Therefore, we used celecoxib (Ce), a well-characterized and specific COX-2 inhibitor, to investigate whether the COX-2/PGE2 signaling pathway participates in the IH-induced exacerbation of malignant processes using a mouse model of OSA bearing Lewis lung carcinoma (LLC1) tumors. The gene discussed is PTGS2; the disease is Carcinoma, Lewis Lung.