It has been proven in melanoma cell lines that EGCG stimulates the activity of PP2A via the 67LR in a cAMP/PKA-dependent manner and this activated PP2A dephosphorylated both phosphorylated CPI-17 and MYPT1pThr696 resulting in MP activation and dephosphorylation of merlin, another MP substrate33. The gene discussed is PTPA; the disease is melanoma.