The overall low frequency of IGRP265-273-specific cells in samples from both type 1 diabetes patients and controls observed in this study is in agreement with previous reports17, 19 that looked at frequencies and phenotypes of CD8+ T cells specific for IGRP and additional autoantigen-specific epitopes, although one of these reports suggested increased frequencies of IGRP-specific CD8+ T cells in patients as compared to controls17. This evidence concerns the gene G6PC2 and type 1 diabetes mellitus.