However, information on the TCR repertoire of autoantigen specific CD8+ T cells in type 1 diabetes is so far limited to the TCR sequencing of propagated CD8+ T cell clones18, TCR sequence information of single TCR chains of isolated bulk autoantigen specific CD8+ T cells19, or CDR3 spectrotype data on bulk autoantigen specific CD8+ T cells20. This evidence concerns the gene CD8A and type 1 diabetes mellitus.