In comparison, 2 out of 90 (2.2%; P < 0.0001) of the TCR α-chains from Flu MP58-66-specific CD8+ T cell clonotypes, 0 out of 18 (0%; P = 0.0015) of the TCR α-chains from CMVpp65-specific CD8+ T cell clonotypes24, and 29 out of 1492 (1.9%, P < 0.0001) TCR α-chains from GAD65- or Tetanus toxoid-specific CD4+ T cell clonotypes analysed in previous studies36 had the SGGSNYKLTF motif arguing for an enrichment of this motif in IGRP-specific cells and against a general bias for this motif in antigen-specific T cells. Here, GAD2 is linked to tetanus.