Although TCR clonotypes can be promiscuous in their binding to MHC-peptide complexes21, TCRs that recognize epitopes of viral and tumour antigens often have preferred CDR3 motifs or gene usage22, 23, 24, 25, 26, indicating that some structural restriction of the MHC-peptide binding region of the TCR plays an important role in the selection and expansion of clones. Here, HLA-C is linked to neoplasm.