However, a more in-depth analysis revealed that the prognostic effect of p140Cap in the consecutive cohort of breast cancer patients was to be ascribed to its performance in the subgroup of ERBB2-amplified breast cancers (Fig. 1c), in which a high p140Cap status predicts a significantly lower probability of developing a distant event (left panel), and a clear difference in survival (right panel). This evidence concerns the gene ERBB2 and breast carcinoma.