The in vivo analysis and the 3D Matrigel-Collagen cultures from primary cancer cells, suggest that p140Cap may limit the aggressiveness of ERBB2 tumours, both increasing tumour differentiation, restoring ‘normal’ mammary epithelial tissue morphogenesis49, 50 and differentially affecting the local tumour microenvironment51. The gene discussed is ERBB2; the disease is neoplasm.