To investigate the role of the endosomal TLRs 3, 7 and 9 on tumour growth, a murine head and neck cancer cell line (murine oropharyngeal carcinoma cell, MOPC) was injected into single KO, double KO and Tlr3/7/9 triple KO mice (Fig. 1a and Supplementary Fig. 1). The gene discussed is TLR3; the disease is head and neck cancer.