PIK3R2 and esophageal cancer: This recruitment leads to activation of critical survival signaling pathways including PI3K, MAPK, NFAT, and NFκB. A luciferase reporter assay showed that miR‐126 can bind the 3′UTR of p85β and reduce reporter activity, and introduction of miR‐126 into colon and esophageal cancer cell lines led to a decrease in p85β protein expression and downstream phosphorylation of protein kinase B (AKT) 10, 11.