These optimum cutoff values were: H-score ≥ 210 for CXCR4+ tumor tissue, CTCs ≥6/7.5 mL blood, and CXCR4+ CTCs ≥7%, and were evaluated by treatment and visit (Supplementary Table S3) or endpoint (Supplementary Table S4). The gene discussed is CXCR4; the disease is neoplasm.